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KMID : 0613820220320010036
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Journal of Life Science
2022 Volume.32 No. 1 p.36 ~ p.43
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Research for Intestinal Mucosal Immunity Induced by Salmonella enteritidis Infection
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Lee Kang-Hee
Lee Se-Hui
Yang Jin-Young
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Abstract
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Mucosal immunity is a well-designed defense system that builds precise and dynamic relationships against pathogens, and the gastrointestinal tract is the most important organ with this system, acting as a guardian at the forefront of its activity. Salmonella spp. cause food poisoning, entering the body orally and mainly invading the Peyer’s patches of the small intestine. Although Salmonella strains share similar mechanisms for inducing innate immunity, different serotypes may have different effects on the intestinal mucosa due to host specificities and pathogenicity. In this study, we evaluated the effects of Salmonella enteritidis infections in mouse intestine and observed significantly reduced dose- dependent survival rates in a challenge test. Flow cytometry data showed no significant differences in intestinal immune cell populations, although histology indicated increased mucin production and decreased goblet cell counts in the Salmonella-treated groups. Furthermore, Claudin expression was significantly decreased in the samples with Salmonella. To investigate the relationship between S. enteritidis infection and inflammatory response, dextran sodium sulfate (DSS) was administered after infection and the results indicate lower survival rate after DSS treatment. In conclusion, we were able to identify the optimal concentration of S. enteritidis to modulate the intestinal mucosal immunity of mice and inflammatory response.
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KEYWORD
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Dextran sodium sulfate (DSS), intestinal inflammation, non-typhoid Salmonella, mucosal immunity, Salmonella enteritidis
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